CRF–CRF(1) system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism...

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Detalhes bibliográficos
Main Authors: George, Olivier, Ghozland, Sandy, Azar, Marc R., Cottone, Pietro, Zorrilla, Eric P., Parsons, Loren H., O'Dell, Laura E., Richardson, Heather N., Koob, George F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040467/
https://ncbi.nlm.nih.gov/pubmed/17921249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707585104
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