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CRF–CRF(1) system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040467/ https://ncbi.nlm.nih.gov/pubmed/17921249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707585104 |
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