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Robust Escalation of Nicotine Intake with Extended Access to Nicotine Self-Administration and Intermittent Periods of Abstinence

Although established smokers have a very regular pattern of smoking behavior, converging lines of evidence suggest that the escalation of smoking behavior is a critical factor in the development of dependence. However, the neurobiological mechanisms that underlie the escalation of smoking are unknow...

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Detalhes bibliográficos
Main Authors: Cohen, Ami, Koob, George F, George, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398720/
https://ncbi.nlm.nih.gov/pubmed/22549121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.67
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