CRF neurons in the ventral tegmental area control the aversive effects of nicotine withdrawal and promote escalation of nicotine intake

Dopaminergic neurons in the ventral tegmental area (VTA) are well known for their role in mediating the positive reinforcing effects of drugs of abuse. Here, we identify in rodents and humans a population of VTA dopamine neurons co-expressing corticotropin releasing factor (CRF). We provide further...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Grieder, Taryn E., Herman, Melissa A., Contet, Candice, Tan, Laura A., Vargas-Perez, Hector, Cohen, Ami, Chwalek, Michal, Maal-Bared, Geith, Freiling, John, Schlosburg, Joel E, Clarke, Laura, Crawford, Elena, Koebel, Pascale, Canonigo, Vez, Sanna, Pietro, Tapper, Andrew, Roberto, Marisa, Kieffer, Brigitte L., Sawchenko, Paul E., Koob, George F., van der Kooy, Derek, George, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241147/
https://ncbi.nlm.nih.gov/pubmed/25402857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3872
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