Recombinant expression, purification, and biophysical characterization of the transmembrane and membrane proximal domains of HIV-1 gp41

The transmembrane subunit (gp41) of the envelope glycoprotein of HIV-1 associates noncovalently with the surface subunit (gp120) and together they play essential roles in viral mucosal transmission and infection of target cells. The membrane proximal region (MPR) of gp41 is highly conserved and cont...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Gong, Zhen, Kessans, Sarah A, Song, Lusheng, Dörner, Katerina, Lee, Ho-Hsien, Meador, Lydia R, LaBaer, Joshua, Hogue, Brenda G, Mor, Tsafrir S, Fromme, Petra
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241111/
https://ncbi.nlm.nih.gov/pubmed/25155369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2540
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