The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region

The membrane-proximal external region (MPER) C-terminal segment and the transmembrane domain (TMD) of gp41 are involved in HIV-1 envelope glycoprotein-mediated fusion and modulation of immune responses during viral infection. However, the atomic structure of this functional region remains unsolved....

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Apellániz, Beatriz, Rujas, Edurne, Serrano, Soraya, Morante, Koldo, Tsumoto, Kouhei, Caaveiro, Jose M. M., Jiménez, M. Ángeles, Nieva, José L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505554/
https://ncbi.nlm.nih.gov/pubmed/25787074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.644351
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