Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10

The 4E10 antibody recognizes the membrane-proximal external region (MPER) of the HIV-1 Env glycoprotein gp41 transmembrane subunit, exhibiting one of the broadest neutralizing activities known to date. The neutralizing activity of 4E10 requires solvent-exposed hydrophobic residues at the apex of the...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Rujas, Edurne, Gulzar, Naveed, Morante, Koldo, Tsumoto, Kouhei, Scott, Jamie K., Nieva, José L., Caaveiro, Jose M. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Structure and Assembly
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645341/
https://ncbi.nlm.nih.gov/pubmed/26378169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01793-15
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