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Peripheral Membrane Interactions Boost the Engagement by an Anti-HIV-1 Broadly Neutralizing Antibody

The 4E10 antibody displays an extreme breadth of HIV-1 neutralization and therefore constitutes a suitable model system for structure-guided vaccine design and immunotherapeutics against AIDS. In this regard, the relevance of autoreactivity with membrane lipids for the biological function of this an...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rujas, Edurne, Caaveiro, José M. M., Insausti, Sara, García-Porras, Miguel, Tsumoto, Kouhei, Nieva, José L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392698/
https://ncbi.nlm.nih.gov/pubmed/28213514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775429
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