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Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

Autophagy, the major lysosomal pathway for the turnover of intracellular organelles is markedly impaired in neurons in Alzheimer’s disease and Alzheimer mouse models. We have previously reported that severe lysosomal and amyloid neuropathology and associated cognitive deficits in the TgCRND8 Alzheim...

詳細記述

保存先:
書誌詳細
出版年:Brain
主要な著者: Yang, Dun-Sheng, Stavrides, Philip, Saito, Mitsuo, Kumar, Asok, Rodriguez-Navarro, Jose A., Pawlik, Monika, Huo, Chunfeng, Walkley, Steven U., Saito, Mariko, Cuervo, Ana M., Nixon, Ralph A.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240291/
https://ncbi.nlm.nih.gov/pubmed/25270989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awu278
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