Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

Autophagy, the major lysosomal pathway for the turnover of intracellular organelles is markedly impaired in neurons in Alzheimer’s disease and Alzheimer mouse models. We have previously reported that severe lysosomal and amyloid neuropathology and associated cognitive deficits in the TgCRND8 Alzheim...

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Bibliografiske detaljer
Udgivet i:Brain
Main Authors: Yang, Dun-Sheng, Stavrides, Philip, Saito, Mitsuo, Kumar, Asok, Rodriguez-Navarro, Jose A., Pawlik, Monika, Huo, Chunfeng, Walkley, Steven U., Saito, Mariko, Cuervo, Ana M., Nixon, Ralph A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240291/
https://ncbi.nlm.nih.gov/pubmed/25270989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awu278
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