A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons

Parkinson's disease (PD), the most common degenerative movement disorder, is caused by a preferential loss of midbrain dopaminergic (mDA) neurons. Both α-synuclein (α-syn) missense and multiplication mutations have been linked to PD. However, the underlying intracellular signalling transduction...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Luo, Jing, Sun, Lixin, Lin, Xian, Liu, Guoxiang, Yu, Jia, Parisiadou, Loukia, Xie, Chengsong, Ding, Jinhui, Cai, Huaibin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240205/
https://ncbi.nlm.nih.gov/pubmed/25051958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu377
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