Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma

Gain-of-function mutations in the olfactomedin domain of the MYOC gene facilitate the toxic accumulation of amyloid-containing myocilin aggregates, hastening the onset of the prevalent ocular disorder primary open-angle glaucoma. Aggregation of wild-type myocilin has been reported in other glaucoma...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hum Mol Genet
Prif Awduron: Stothert, Andrew R., Suntharalingam, Amirthaa, Huard, Dustin J. E., Fontaine, Sarah N., Crowley, Vincent M., Mishra, Sanket, Blagg, Brian S. J., Lieberman, Raquel L., Dickey, Chad A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2014
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240202/
https://ncbi.nlm.nih.gov/pubmed/25027323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu367
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