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Microscopic Detection of Quenched Activity Based Optical Imaging Probes Using an Antibody Detection System: Localizing Protease Activity

PURPOSE: The cysteine cathepsins are a family of proteases that play important physiological roles in both normal cellular physiology and many human diseases. In cancer, the activity of many of the cysteine cathepsins is up-regulated and can be exploited for tumor imaging both in vivo and ex vivo. T...

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Detalhes bibliográficos
Publicado no:Mol Imaging Biol
Main Authors: Walker, Ethan, Gopalakrishnan, Ramamurthy, Bogyo, Matthew, Basilion, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240007/
https://ncbi.nlm.nih.gov/pubmed/24705781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-014-0736-1
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