BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

Recent studies have revealed that p27, a nuclear cyclin-dependent kinase (Cdk) inhibitor and tumor suppressor, can acquire oncogenic activities upon mislocalization to the cytoplasm. To understand how these antagonistic activities influence oncogenesis, we dissected the nuclear and cytoplasmic funct...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Agarwal, Anupriya, Mackenzie, Ryan J., Besson, Arnaud, Jeng, Sophia, Carey, Alyssa, LaTocha, Dorian H., Fleischman, Angela G., Duquesnes, Nicolas, Eide, Christopher A., Vasudevan, Kavin B., Loriaux, Marc M., Firpo, Eduardo, Cortes, Jorge E., McWeeney, Shannon, O’Hare, Thomas, Roberts, James M., Druker, Brian J., Deininger, Michael W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2014
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239335/
https://ncbi.nlm.nih.gov/pubmed/25293778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-497040
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