Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres

Telomere shortening limits the proliferative capacity of human cells, and age-dependent shortening of telomeres occurs in somatic tissues including hematopoietic stem cells (HSCs). It is currently unknown whether genomic and molecular damage that occurs in HSCs induced by telomere shortening is tran...

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Udgivet i:Blood
Main Authors: Wang, Jianwei, Lu, Xin, Sakk, Vadim, Klein, Christoph A., Rudolph, Karl Lenhard
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2014
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239332/
https://ncbi.nlm.nih.gov/pubmed/25232057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-568055
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