Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial

PURPOSE: Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid conformally the hippocampal neural stem-cell compartment during WBRT (HA-WBRT). RTOG 0933 was a single-arm phase II study of HA...

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Pubblicato in:J Clin Oncol
Autori principali: Gondi, Vinai, Pugh, Stephanie L., Tome, Wolfgang A., Caine, Chip, Corn, Ben, Kanner, Andrew, Rowley, Howard, Kundapur, Vijayananda, DeNittis, Albert, Greenspoon, Jeffrey N., Konski, Andre A., Bauman, Glenn S., Shah, Sunjay, Shi, Wenyin, Wendland, Merideth, Kachnic, Lisa, Mehta, Minesh P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2014
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239303/
https://ncbi.nlm.nih.gov/pubmed/25349290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.57.2909
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