NCOG-02. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933

PURPOSE: RTOG 0933 demonstrated benefits to memory following HA-WBRT, supporting the hypothesis of hippocampal radiosensitivity and associated memory specificity. However, some patients demonstrated cognitive decline, suggesting mechanisms outside hippocampal radiosensitivity playing a role. WMI has...

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Vydáno v:Neuro Oncol
Hlavní autoři: Bovi, Joseph, Pugh, Stephanie L, Sabsevitz, David, Robinson, Clifford G, Paulson, Eric, Mehta, Minesh P, Gondi, Vinai, Kundapur, Vijayananda, Pinover, Wayne H, Chao, Samuel T, Machtay, Mitch, DeNittis, Albert S, Laack, Nadia N, Greenspoon, Jeffrey N, Mannel, Robert S, Huang, Jiayi, Dominello, Michael M, Kachnic, Lisa A
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692045/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.563
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