RADI-04. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933

PURPOSE: RTOG 0933 demonstrated benefits to memory following HA-WBRT, supporting the hypothesis of hippocampal radiosensitivity and associated memory specificity. However, some patients demonstrated cognitive decline, suggesting mechanisms outside hippocampal radiosensitivity playing a role. WMI has...

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Publicado no:Neurooncol Adv
Principais autores: Bovi, Joseph, Pugh, Stephanie, Sabesevitz, David, Robinson, Clifford, Paulson, Eric, Mehta, Minesh, Gondi, Vinai, Kundapur, Vijayananda, Pinover, Wayne, Chao, Samuel, Machtay, Mitchell, DeNittis, Albert, Laack, Nadia, Greenspoon, Jeffrey, Mannel, Robert, Huang, Jiayi, Dominello, Michael, Kachnic, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213231/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz014.097
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