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Hemoglobin α / eNOS Coupling at Myoendothelial Junctions is Required for Nitric Oxide Scavenging During Vasoconstriction

OBJECTIVE: Hb α and eNOS form a macromolecular complex at myoendothelial junctions; the functional role of this interaction remains undefined. To test if coupling of eNOS and Hb α regulates NO signaling, vascular reactivity and blood pressure using a mimetic peptide of Hb α to disrupt this interacti...

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Bibliographische Detailangaben
Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Straub, Adam C., Butcher, Joshua T., Billaud, Marie, Mutchler, Stephanie M., Artamonov, Mykhaylo V., Nguyen, Anh T., Johnson, Tyler, Best, Angela K., Miller, Megan P., Palmer, Lisa A., Columbus, Linda, Somlyo, Avril V., Le, Thu H., Isakson, Brant E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239174/
https://ncbi.nlm.nih.gov/pubmed/25278292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.303974
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