Differential Interaction Kinetics of a Bipolar Structure-Specific Endonuclease with DNA Flaps Revealed by Single-Molecule Imaging

As DNA repair enzymes are essential for preserving genome integrity, understanding their substrate interaction dynamics and the regulation of their catalytic mechanisms is crucial. Using single-molecule imaging, we investigated the association and dissociation kinetics of the bipolar endonuclease Nu...

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Publicado en:PLoS One
Main Authors: Rezgui, Rachid, Lestini, Roxane, Kühn, Joëlle, Fave, Xenia, McLeod, Lauren, Myllykallio, Hannu, Alexandrou, Antigoni, Bouzigues, Cedric
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239081/
https://ncbi.nlm.nih.gov/pubmed/25412080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113493
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