Structure and function of a novel endonuclease acting on branched DNA substrates

We show that Pyrococcus abyssi PAB2263 (dubbed NucS (nuclease for ss DNA) is a novel archaeal endonuclease that interacts with the replication clamp PCNA. Structural determination of P. abyssi NucS revealed a two-domain dumbbell-like structure that in overall does not resemble any known protein stru...

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Autors principals: Ren, Bin, Kühn, Joelle, Meslet-Cladiere, Laurence, Briffotaux, Julien, Norais, Cedric, Lavigne, Regis, Flament, Didier, Ladenstein, Rudolf, Myllykallio, Hannu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735178/
https://ncbi.nlm.nih.gov/pubmed/19609302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.192
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