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Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells

Mouse embryonic stem cells (mESCs) are self-renewing and capable of differentiating into any of the three germ layers. An interesting feature of mESCs is the presence of cell-to-cell heterogeneity in gene expression that may be responsible for cell fate decisions. Nanog, a key transcription factor f...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Ochiai, Hiroshi, Sugawara, Takeshi, Sakuma, Tetsushi, Yamamoto, Takashi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238020/
https://ncbi.nlm.nih.gov/pubmed/25410303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07125
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