Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

BACKGROUND: The 5XFAD early onset mouse model of Alzheimer’s disease (AD) is gaining momentum. Behavioral, electrophysiological and anatomical studies have identified age-dependent alterations that can be reminiscent of human AD. However, transcriptional changes during disease progression have not y...

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Udgivet i:Mol Neurodegener
Main Authors: Landel, Véréna, Baranger, Kévin, Virard, Isabelle, Loriod, Béatrice, Khrestchatisky, Michel, Rivera, Santiago, Benech, Philippe, Féron, François
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237952/
https://ncbi.nlm.nih.gov/pubmed/25213090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-33
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