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Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs

Gene therapy with adeno-associated virus (AAV) has advanced in the last few years from promising results in animal models to >100 clinical trials (reported or under way). While vector availability was a substantial hurdle a decade ago, innovative new production methods now routinely match the sca...

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Detalhes bibliográficos
Publicado no:Mol Pain
Main Authors: Pleticha, Josef, Heilmann, Lukas F, Evans, Christopher H, Asokan, Aravind, Samulski, Richard Jude, Beutler, Andreas S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237902/
https://ncbi.nlm.nih.gov/pubmed/25183392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-10-54
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