Concurrent Deletion of Cyclin E1 and Cyclin-Dependent Kinase 2 in Hepatocytes Inhibits DNA Replication and Liver Regeneration in Mice

The liver has a strong regenerative capacity. After injury, quiescent hepatocytes can reenter the mitotic cell cycle to restore tissue homeostasis. This G(0)/G(1)-S cell-cycle transition of primed hepatocytes is regulated by complexes of cyclin-dependent kinase 2 (Cdk2) with E-type cyclins (CcnE1 or...

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Veröffentlicht in:Hepatology
Hauptverfasser: Hu, Wei, Nevzorova, Yulia A., Haas, Ute, Moro, Nives, Sicinski, Piotr, Geng, Yan, Barbacid, Mariano, Trautwein, Christian, Liedtke, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236539/
https://ncbi.nlm.nih.gov/pubmed/23787781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26584
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