Oligodendrocyte Precursor Cell-Intrinsic Effect of Rheb1 Controls Differentiation and Mediates mTORC1-Dependent Myelination in Brain

Rheb1 is an immediate early gene that functions to activate mammalian target of rapamycin (mTor) selectively in complex 1 (mTORC1). We have demonstrated previously that Rheb1 is essential for myelination in the CNS using a Nestin-Cre driver line that deletes Rheb1 in all neural cell lineages, and re...

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Udgivet i:J Neurosci
Main Authors: Zou, Yi, Jiang, Wanxiang, Wang, Jianqing, Li, Zhongping, Zhang, Junyan, Bu, Jicheng, Zou, Jia, Zhou, Liang, Yu, Shouyang, Cui, Yiyuan, Yang, Weiwei, Luo, Liping, Lu, Qing R., Liu, Yanhui, Chen, Mina, Worley, Paul F., Xiao, Bo
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236405/
https://ncbi.nlm.nih.gov/pubmed/25411504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2267-14.2014
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