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The mechanisms behind the therapeutic activity of BET bromodomain inhibition
The bromodomain and extra-terminal (BET) protein Brd4 recruits transcriptional regulatory complexes to acetylated chromatin. While Brd4 is considered to be a general transcriptional regulator, pharmacological inhibition of BET proteins shows therapeutic activity in a variety of different pathologies...
Shranjeno v:
| izdano v: | Mol Cell |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4236231/ https://ncbi.nlm.nih.gov/pubmed/24905006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.05.016 |
| Oznake: |
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