Limitation of immune tolerance–inducing thymic epithelial cell development by Spi-B–mediated negative feedback regulation

Medullary thymic epithelial cells (mTECs) expressing the autoimmune regulator AIRE and various tissue-specific antigens (TSAs) are critical for preventing the onset of autoimmunity and may attenuate tumor immunity. However, molecular mechanisms controlling mTEC development remain elusive. Here, we d...

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Udgivet i:J Exp Med
Main Authors: Akiyama, Nobuko, Shinzawa, Miho, Miyauchi, Maki, Yanai, Hiromi, Tateishi, Ryosuke, Shimo, Yusuke, Ohshima, Daisuke, Matsuo, Koichi, Sasaki, Izumi, Hoshino, Katsuaki, Wu, Guoying, Yagi, Shintaro, Inoue, Jun-ichiro, Kaisho, Tsuneyasu, Akiyama, Taishin
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235644/
https://ncbi.nlm.nih.gov/pubmed/25385757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141207
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