Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma

We report that 10% of melanoma tumors and cell lines harbor mutations in the fibroblast growth factor receptor 2 (FGFR2) gene. These novel mutations include three truncating mutations and 20 missense mutations occurring at evolutionary conserved residues in FGFR2 as well as among all four FGFRs. The...

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Publicado no:Mol Cancer Res
Main Authors: Gartside, Michael G., Chen, Huaibin, Ibrahimi, Omar A., Byron, Sara A., Curtis, Amy V., Wellens, Candice L., Bengston, Ana, Yudt, Laura M., Eliseenkova, Anna V., Ma, Jinghong, Curtin, John A., Hyder, Pilar, Harper, Ursula L., Riedesel, Erica, Mann, Graham J., Trent, Jeffrey M., Bastian, Boris C., Meltzer, Paul S., Mohammadi, Moosa, Pollock, Pamela M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233648/
https://ncbi.nlm.nih.gov/pubmed/19147536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0021
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