Discovery of Highly Potent Dual CysLT(1) and CysLT(2) Antagonist

[Image: see text] The benzoxazine derivative, (2S)-4-(3-carboxypropyl)-8-{[4-(4-phenylbutoxy)benzoyl]amino}-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid (19, ONO-2050297), was identified as the first potent dual CysLT(1) and CysLT(2) antagonist with IC(50) values of 0.017 μM (CysLT(1)) and 0.000...

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Bibliografski detalji
Izdano u:ACS Med Chem Lett
Glavni autori: Itadani, Satoshi, Takahashi, Shinya, Ima, Masaki, Sekiguchi, Tetsuya, Fujita, Manabu, Nakayama, Yoshisuke, Takeuchi, Jun
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233365/
https://ncbi.nlm.nih.gov/pubmed/25408836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500298y
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