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Discovery of Highly Potent Dual CysLT(1) and CysLT(2) Antagonist
[Image: see text] The benzoxazine derivative, (2S)-4-(3-carboxypropyl)-8-{[4-(4-phenylbutoxy)benzoyl]amino}-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid (19, ONO-2050297), was identified as the first potent dual CysLT(1) and CysLT(2) antagonist with IC(50) values of 0.017 μM (CysLT(1)) and 0.000...
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| Publicat a: | ACS Med Chem Lett |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2014
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4233365/ https://ncbi.nlm.nih.gov/pubmed/25408836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500298y |
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