Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands

[Image: see text] We report the synthesis and characterization of a series of enantiopure 5-cyclopropane-bearing pyridyldiazabicyclo[3.3.0]octanes that display low nanomolar binding affinities and act as functional agonists at α4β2-nicotinic acetylcholine receptor (nAChR) subtype. Structure–activity...

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Udgivet i:ACS Med Chem Lett
Main Authors: Onajole, Oluseye K., Eaton, J. Brek, Lukas, Ronald J., Brunner, Dani, Thiede, Lucinda, Caldarone, Barbara J., Kozikowski, Alan P.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233362/
https://ncbi.nlm.nih.gov/pubmed/25408831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500129k
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