Dihydropyrrolo[2,3-d]pyrimidines: Selective Toll-Like Receptor 9 Antagonists from Scaffold Morphing Efforts

[Image: see text] Toll-like receptors (TLRs) play important roles in the innate immune system. In fact, recognition of endogenous immune complexes containing self-nucleic acids as pathogen- or damage-associated molecular patterns contributes to certain autoimmune diseases, and inhibition of these re...

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Publicat a:ACS Med Chem Lett
Autors principals: Watanabe, Manabu, Kasai, Mai, Tomizawa, Hideyuki, Aoki, Masamitsu, Eiho, Kazuo, Isobe, Yoshiaki, Asano, Shigehiro
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233361/
https://ncbi.nlm.nih.gov/pubmed/25408837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5003184
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