Benzimidazoles: Novel Mycobacterial Gyrase Inhibitors from Scaffold Morphing

[Image: see text] Type II topoisomerases are well conserved across the bacterial species, and inhibition of DNA gyrase by fluoroquinolones has provided an attractive option for treatment of tuberculosis (TB). However, the emergence of fluoroquinolone-resistant strains of Mycobacterium tuberculosis (...

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Detalhes bibliográficos
Main Authors: Hameed P, Shahul, Raichurkar, Anandkumar, Madhavapeddi, Prashanti, Menasinakai, Sreenivasaiah, Sharma, Sreevalli, Kaur, Parvinder, Nandishaiah, Radha, Panduga, Vijender, Reddy, Jitendar, Sambandamurthy, Vasan K., Sriram, D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094266/
https://ncbi.nlm.nih.gov/pubmed/25050172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5001728
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