Benzimidazoles: Novel Mycobacterial Gyrase Inhibitors from Scaffold Morphing

[Image: see text] Type II topoisomerases are well conserved across the bacterial species, and inhibition of DNA gyrase by fluoroquinolones has provided an attractive option for treatment of tuberculosis (TB). However, the emergence of fluoroquinolone-resistant strains of Mycobacterium tuberculosis (...

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Autors principals: Hameed P, Shahul, Raichurkar, Anandkumar, Madhavapeddi, Prashanti, Menasinakai, Sreenivasaiah, Sharma, Sreevalli, Kaur, Parvinder, Nandishaiah, Radha, Panduga, Vijender, Reddy, Jitendar, Sambandamurthy, Vasan K., Sriram, D.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094266/
https://ncbi.nlm.nih.gov/pubmed/25050172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5001728
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