Optimization of Pyrrolamides as Mycobacterial GyrB ATPase Inhibitors: Structure-Activity Relationship and In Vivo Efficacy in a Mouse Model of Tuberculosis

Moxifloxacin has shown excellent activity against drug-sensitive as well as drug-resistant tuberculosis (TB), thus confirming DNA gyrase as a clinically validated target for discovering novel anti-TB agents. We have identified novel inhibitors in the pyrrolamide class which kill Mycobacterium tuberc...

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Detaylı Bibliyografya
Asıl Yazarlar: P, Shahul Hameed, Solapure, Suresh, Mukherjee, Kakoli, Nandi, Vrinda, Waterson, David, Shandil, Radha, Balganesh, Meenakshi, Sambandamurthy, Vasan K., Raichurkar, Anand Kumar, Deshpande, Abhijeet, Ghosh, Anirban, Awasthy, Disha, Shanbhag, Gajanan, Sheikh, Gulebahar, McMiken, Helen, Puttur, Jayashree, Reddy, Jitendar, Werngren, Jim, Read, Jon, Kumar, Mahesh, R, Manjunatha, Chinnapattu, Murugan, Madhavapeddi, Prashanti, Manjrekar, Praveena, Basu, Reetobrata, Gaonkar, Sheshagiri, Sharma, Sreevalli, Hoffner, Sven, Humnabadkar, Vaishali, Subbulakshmi, Venkita, Panduga, Vijender
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2014
Konular:
Experimental Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910769/
https://ncbi.nlm.nih.gov/pubmed/24126580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01751-13
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