Synthesis and Biological Evaluation of Sophoridinol Derivatives as a Novel Family of Potential Anticancer Agents

[Image: see text] New N-substituted sophoridinic acid/ester and sophoridinol derivatives were synthesized and evaluated for their cytotoxic activity in human HepG2 hepatoma cells from the lead sophoridine (1). Among the newly synthesized compounds, sophoridinol 7i displayed a potential antiprolifera...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Bi, Chongwen, Zhang, Caixia, Li, Yinghong, Tang, Sheng, Wang, Shenggang, Shao, Rongguang, Fu, Haigen, Su, Feng, Song, Danqing
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233360/
https://ncbi.nlm.nih.gov/pubmed/25408835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500289h
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