Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors

[Image: see text] In the search for novel Gram-negative agents, we performed a comprehensive search of the AstraZeneca collection and identified a tetrahydropyran-based matrix metalloprotease (MMP) inhibitor that demonstrated nanomolar inhibition of UDP-3-O-(acyl)-N-acetylglucosamine deacetylase (Lp...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Murphy-Benenato, Kerry E., Olivier, Nelson, Choy, Allison, Ross, Philip L., Miller, Matthew D., Thresher, Jason, Gao, Ning, Hale, Michael R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233352/
https://ncbi.nlm.nih.gov/pubmed/25408833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500210x
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