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Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors
[Image: see text] In the search for novel Gram-negative agents, we performed a comprehensive search of the AstraZeneca collection and identified a tetrahydropyran-based matrix metalloprotease (MMP) inhibitor that demonstrated nanomolar inhibition of UDP-3-O-(acyl)-N-acetylglucosamine deacetylase (Lp...
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| Veröffentlicht in: | ACS Med Chem Lett |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4233352/ https://ncbi.nlm.nih.gov/pubmed/25408833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500210x |
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