Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes

Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated either by an endonucleolytic cleavage event near the PTC or through decapping, the individual contribution of these activities on endogenous...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Lykke-Andersen, Søren, Chen, Yun, Ardal, Britt R., Lilje, Berit, Waage, Johannes, Sandelin, Albin, Jensen, Torben Heick
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233243/
https://ncbi.nlm.nih.gov/pubmed/25403180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.246538.114
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