Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes

Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated either by an endonucleolytic cleavage event near the PTC or through decapping, the individual contribution of these activities on endogenous...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Lykke-Andersen, Søren, Chen, Yun, Ardal, Britt R., Lilje, Berit, Waage, Johannes, Sandelin, Albin, Jensen, Torben Heick
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233243/
https://ncbi.nlm.nih.gov/pubmed/25403180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.246538.114
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