Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes

Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated either by an endonucleolytic cleavage event near the PTC or through decapping, the individual contribution of these activities on endogenous...

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Publicat a:Genes Dev
Autors principals: Lykke-Andersen, Søren, Chen, Yun, Ardal, Britt R., Lilje, Berit, Waage, Johannes, Sandelin, Albin, Jensen, Torben Heick
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233243/
https://ncbi.nlm.nih.gov/pubmed/25403180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.246538.114
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