TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

The semiconservative replication of telomeres is facilitated by the shelterin component TRF1. Without TRF1, replication forks stall in the telomeric repeats, leading to ATR kinase signaling upon S-phase progression, fragile metaphase telomeres that resemble the common fragile sites (CFSs), and the a...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Zimmermann, Michal, Kibe, Tatsuya, Kabir, Shaheen, de Lange, Titia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2014
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233241/
https://ncbi.nlm.nih.gov/pubmed/25344324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.251611.114
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi