Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice

Presynaptic acetylcholine (ACh) synthesis and release is thought to be sustained by a hemicholinium-3-sensitive choline transporter (CHT). We disrupted the murine CHT gene and examined CHT–/– and +/– animals for evidence of impaired cholinergic neurotransmission. Although morphologically normal at b...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ferguson, Shawn M., Bazalakova, Mihaela, Savchenko, Valentina, Tapia, Juan Carlos, Wright, Jane, Blakely, Randy D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423269/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15173594/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401667101
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