Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice

Presynaptic acetylcholine (ACh) synthesis and release is thought to be sustained by a hemicholinium-3-sensitive choline transporter (CHT). We disrupted the murine CHT gene and examined CHT–/– and +/– animals for evidence of impaired cholinergic neurotransmission. Although morphologically normal at b...

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Autori principali: Ferguson, Shawn M., Bazalakova, Mihaela, Savchenko, Valentina, Tapia, Juan Carlos, Wright, Jane, Blakely, Randy D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC423269/
https://ncbi.nlm.nih.gov/pubmed/15173594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401667101
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