A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium report(†)

BACKGROUND: A phase I trial of veliparib (ABT-888), an oral poly(ADP-ribose) polymerase (PARP) inhibitor, and temozolomide (TMZ) was conducted in children with recurrent brain tumors to (i) estimate the maximum tolerated doses (MTDs) or recommended phase II doses (RP2Ds) of veliparib and TMZ; (ii) d...

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發表在:Neuro Oncol
Main Authors: Su, Jack M., Thompson, Patrick, Adesina, Adekunle, Li, Xiao-Nan, Kilburn, Lindsay, Onar-Thomas, Arzu, Kocak, Mehmet, Chyla, Brenda, McKeegan, Evelyn, Warren, Katherine E., Goldman, Stewart, Pollack, Ian F., Fouladi, Maryam, Chen, Alice, Giranda, Vincent, Boyett, James, Kun, Larry, Blaney, Susan M.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2014
主題:
Pediatric Neuro-Oncology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232081/
https://ncbi.nlm.nih.gov/pubmed/24908656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou103
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