Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca(2+) transporters in individual hypoglossal motor neurons of endstage SOD1 transgenic mice

Disturbances in Ca(2+) homeostasis and mitochondrial dysfunction have emerged as major pathogenic features in familial and sporadic forms of Amyotrophic Lateral Sclerosis (ALS), a fatal degenerative motor neuron disease. However, the distinct molecular ALS-pathology remains unclear. Recently, an act...

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Udgivet i:Front Cell Neurosci
Main Authors: Mühling, Tobias, Duda, Johanna, Weishaupt, Jochen H., Ludolph, Albert C., Liss, Birgit
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2014
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231948/
https://ncbi.nlm.nih.gov/pubmed/25452714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00353
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