Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy

Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important in maintaining HIV latency and histone deacetylase inhibitors (HDACi) may reverse latency by activating HIV transcript...

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Publicat a:PLoS Pathog
Autors principals: Elliott, Julian H., Wightman, Fiona, Solomon, Ajantha, Ghneim, Khader, Ahlers, Jeffrey, Cameron, Mark J., Smith, Miranda Z., Spelman, Tim, McMahon, James, Velayudham, Pushparaj, Brown, Gregor, Roney, Janine, Watson, Jo, Prince, Miles H., Hoy, Jennifer F., Chomont, Nicolas, Fromentin, Rémi, Procopio, Francesco A., Zeidan, Joumana, Palmer, Sarah, Odevall, Lina, Johnstone, Ricky W., Martin, Ben P., Sinclair, Elizabeth, Deeks, Steven G., Hazuda, Daria J., Cameron, Paul U., Sékaly, Rafick-Pierre, Lewin, Sharon R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231123/
https://ncbi.nlm.nih.gov/pubmed/25393648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004473
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