Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy

Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important in maintaining HIV latency and histone deacetylase inhibitors (HDACi) may reverse latency by activating HIV transcript...

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Udgivet i:PLoS Pathog
Main Authors: Elliott, Julian H., Wightman, Fiona, Solomon, Ajantha, Ghneim, Khader, Ahlers, Jeffrey, Cameron, Mark J., Smith, Miranda Z., Spelman, Tim, McMahon, James, Velayudham, Pushparaj, Brown, Gregor, Roney, Janine, Watson, Jo, Prince, Miles H., Hoy, Jennifer F., Chomont, Nicolas, Fromentin, Rémi, Procopio, Francesco A., Zeidan, Joumana, Palmer, Sarah, Odevall, Lina, Johnstone, Ricky W., Martin, Ben P., Sinclair, Elizabeth, Deeks, Steven G., Hazuda, Daria J., Cameron, Paul U., Sékaly, Rafick-Pierre, Lewin, Sharon R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231123/
https://ncbi.nlm.nih.gov/pubmed/25393648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004473
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