Hidden Disease Susceptibility and Sexual Dimorphism in the Heterozygous Knockout of Cyp51 from Cholesterol Synthesis

We examined the genotype-phenotype interactions of Cyp51(+/−) mice carrying one functional allele of lanosterol 14α-demethylase from cholesterol biosynthesis. No distinct developmental or morphological abnormalities were observed by routine visual inspection of Cyp51(+/−) and Cyp51(+/+) mice and fer...

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Publicat a:PLoS One
Autors principals: Lewinska, Monika, Juvan, Peter, Perse, Martina, Jeruc, Jera, Kos, Spela, Lorbek, Gregor, Urlep, Ziga, Keber, Rok, Horvat, Simon, Rozman, Damjana
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231084/
https://ncbi.nlm.nih.gov/pubmed/25393872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112787
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